Punchinello was the American spinoff of Punch magazine.
Punchinello may also refer to:
- A magazine published in New York City, USA, from April through December of 1870
- The third main boss in the Super Nintendo video game Super Mario RPG: Legend of the Seven Stars
- The main character in Max Lucado's 1997 book, You Are Special and subsequent books about Lucado's fictional society of wooden people called the "Wemmicks"
- The Punchinello Crime Family and its leader, Don Angelo Punchinello, the main antagonists for the first couple of chapters of the video game Max Payne